Retro-2 cycl
Cat. No.：YN250238
CAS No. ：1429192-00-6
| 产品名称: | Retro-2 cycl |
| CAS No.: | 1429192-00-6 |
| Chemical Name: | 2,3-dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone |
| Synonyms: | RN 1-001 |
| 分子量: | 320.41 |
| 分子式: | C₁₉H₁₆N₂OS |
| SMILES: | O=C1C2=CC=CC=C2NC(N1C3=CC=CC=C3)C4=CC=C(S4)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Retro-2 cycl (RN 1-001) 是一种逆行运输抑制剂。Retro-2 cycl (RN 1-001) 抑制 JCPyV 和 HPV16 伪病毒，IC50分别为 54 μM 和 160 μM。 |
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Nonnenmacher, M.E., Cintrat, J.C., Gillet, D., et al.Syntaxin 5-dependent retrograde transport to the trans-Golgi network is required for adeno-associated virus transductionJ. Virol.89(3),1673-1687(2015)
Stechmann, B., Bai, S.K., Gobbo, E., et al.Inhibition of retrograde transport protects mice from lethal ricin challengeCell141(2),231-242(2010)
Shtanko, O., Sakurai, Y., Reyes, A.N., et al.Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infectionAntiviral Res.149,154-163(2018)
Nelson, C.D., Carney, D.W., Derdowski, A., et al.A retrograde trafficking inhibitor of ricin and Shiga-like toxins inhibits infection of cells by human and monkey polyomavirusesMBio4(6),e00729-00713(2013)
Secher, T., Shima, A., Hinsinger, K., et al.Retrograde trafficking inhibitor of Shiga toxins reduces morbidity and mortality of mice infected with enterohemorrhagic Escherichia coliAntimicrob. Agents Chemother.59(8),5010-5013(2015)
