Tubacin
Cat. No.：YN250479
| 产品名称: | Tubacin |
| CAS No.: | 537049-40-4 |
| Chemical Name: | N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide |
| Synonyms: | |
| 分子量: | 721.86 |
| 分子式: | C₄₁H₄₃N₃O₇S |
| SMILES: | OCC(C=C1)=CC=C1[C@@H]2C[C@H](CSC3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)O[C@H](C6=CC=C(NC(CCCCCCC(NO)=O)=O)C=C6)O2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tubacin 是一种有效的，选择性的HDAC6抑制剂，IC50值为 4 nM，大约是对 HDAC1 的 350 倍。 |
| IC50和靶点: | [{name:"HDAC6:4 nM (IC50)"},{name: "HDAC3:1.27 μM (IC50)"},{name: "HDAC8:1.27 μM (IC50)"},{name: "HDAC1:1.40 μM (IC50)"},{name: "HDAC5:3.35 μM (IC50)"},{name: "HDAC10:3.71 μM (IC50)"},{name: "HDAC11:3.79 μM (IC50)"},{name: "HDAC9:4.31 μM (IC50)"},{name: "HDAC2:6.27 μM (IC50)"},{name: "HDAC7:9.70 μM (IC50)"},{name: "HDAC4:17.30 μM (IC50)"}] |
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Butler, K.V., Kalin, J., Brochier, C., et al.Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, Tubastatin AJ. Am. Chem. Soc.132(31),10842-10846(2010)
Chen, S., Owens, G.C., Makarenkova, H., et al.HDAC6 regulates mitochondrial transport in hippocampal neuronsPLoS One5(5),(2010)
Cole, P.A.Chemical probes for histone-modifying enzymesNat. Chem. Biol.4(10),590-597(2008)
Xu, K., Dai, X.L., Huang, H.C., et al.Targeting HDACs: A promising therapy for Alzheimer's diseaseOxid. Med. Cell. Longev.,143269(2011)
