SRPIN340
Cat. No.：YN250576
CAS No. ：218156-96-8
| 产品名称: | SRPIN340 |
| CAS No.: | 218156-96-8 |
| Chemical Name: | N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide |
| Synonyms: | SRPK inhibitor |
| 分子量: | 349.35 |
| 分子式: | C₁₈H₁₈F₃N₃O |
| SMILES: | O=C(NC1=CC(C(F)(F)F)=CC=C1N2CCCCC2)C3=CC=NC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SRPIN340 是一种 ATP 竞争性的SRPK抑制剂，能够抑制 SRPK1 的活性，Ki值为 0.89 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Ghosh, G., and Adams, J.A.Phosphorylation mechanism and structure of serine-arginine protein kinasesFEBS J.278(4),587-597(2011)
Fukuhara, T., Hosoya, T., Shimizu, S., et al.Utilization of host SR protein kinases and RNA-splicing machinery during viral replicationProc. Natl. Acad. Sci. USA103(30),11329-11333(2006)
Karakama, Y., Sakamoto, N., Itsui, Y., et al.Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinaseAntimicrob. Agents Chemother.54(8),3179-3186(2010)
Ghadimi, M.P., Lopez, G., Torres, K.E., et al.Targeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumorsMol. Cancer Ther.11(8),1758-1769(2012)
Gammons, M.V.R., Dick, A.D., Harper, S.J., et al.SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurityInvest. Ophthalmol. Vis. Sci.54(8),5797-5806(2013)
Dong, Z., Noda, K., Kanda, A., et al.Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularizationMol. Vis.19,536-543(2013)
