ESI-09
Cat. No.：YN250675
CAS No. ：263707-16-0
| 产品名称: | ESI-09 |
| CAS No.: | 263707-16-0 |
| Chemical Name: | α-[2-(3-chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile |
| Synonyms: | ESI-09,ESI 09,ESI09 |
| 分子量: | 330.77 |
| 分子式: | C₁₆H₁₅ClN₄O₂ |
| SMILES: | O=C(C1=NOC(C(C)(C)C)=C1)/C(C#N)=N/NC2=CC(Cl)=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ESI-09是新型非环状核苷酸EPAC的拮抗剂，抑制EPAC1 and EPAC2的IC50值分别为3.2和1.4 μM。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Almahariq, M., Tsalkova, T., Mei, F.C., et al.A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasionMol. Pharmacol.83(1),122-128(2013)
Zhu, Y., Chen, H., Boulton, S., et al.Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: Defining the ESI-09 "therapeutic window"Sci. Rep.5:9344,(2015)
