SKL2001
Cat. No.：YN450014
CAS No. ：909089-13-0
规格
价格(RMB)
库存
| 产品名称: | SKL2001 |
| CAS No.: | 909089-13-0 |
| Chemical Name: | 5-(2-furanyl)-N-[3-(1H-imidazol-1-yl)propyl]-3-isoxazolecarboxamide |
| Synonyms: | SKL2001,SKL-2001,SKL 2001 |
| 分子量: | 286.29 |
| 分子式: | C₁₄H₁₄N₄O₃ |
| SMILES: | O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=CN=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SKL2001 是Wnt/β-catenin信号通路的激动剂，具有抗肿瘤活性。SKL2001 通过破坏 Axin/β-catenin 相互作用，稳定细胞内 β-catenin。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Gwak, J., Hwang, S.G., Park, H.S., et al.Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiationCell Res.22(1),237-247(2012)
Ohashi, W., Yamamine, N., Imura, J., et al.SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complexBiochem. Biophys. Res. Commun.493(3),1342-1348(2017)
