HLY78
Cat. No.：YN450054
CAS No. ：854847-61-3
规格
价格(RMB)
库存
| 产品名称: | HLY78 |
| CAS No.: | 854847-61-3 |
| Chemical Name: | 4-ethyl-5,6-dihydro-5-methyl-[1,3]dioxolo[4,5-j]phenanthridine |
| Synonyms: | 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine |
| 分子量: | 267.32 |
| 分子式: | C₁₇H₁₇NO₂ |
| SMILES: | CCC1=CC=CC2=C1N(CC3=CC4=C(C=C32)OCO4)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HLY78 是一种Wnt/β-catenin信号通路的激活剂，通过靶向通道中 Axin 的 DIX 域，强化 Axin-LRP6 交联来促进 Wnt 信号转导。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Polakis, P.Wnt signaling and cancerGenes Dev.14(15),1837-1851(2000)
Reya, T., and Clevers, H.Wnt signalling in stem cells and cancerNature434(7035),834-850(2005)
Clevers, H.Wnt/β-catenin signaling in development and diseaseCell127(3),469-480(2006)
Wang, S., Yin, J., Chen, D., et al.Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interactionNat. Chem. Biol.9,579-585(2013)
