IWP-4
Cat. No.:YN450070
产品名称: | IWP-4 |
CAS No.: | 686772-17-8 |
Chemical Name: | N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-acetamide |
Synonyms: | Inhibitor of Wnt Production-4 |
分子量: | 496.62 |
分子式: | C₂₃H₂₀N₄O₃S₃ |
SMILES: | O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5OC)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | IWP-4 是一种小分子Wnt抑制剂,其IC50值为 25 nM。 |
IC50和靶点: | |
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Chen, B., Dodge, M.E., Tang, W., et al.Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancerNat. Chem. Biol.5(2),100-107(2009)
Lian, X., Hsiao, C., Wilson, G., et al.Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signalingProc. Natl. Acad. Sci. USA,E1848-E1857(2012)