Prinaberel
Cat. No.：YN450092
CAS No. ：524684-52-4
规格
价格(RMB)
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| 产品名称: | Prinaberel |
| CAS No.: | 524684-52-4 |
| Chemical Name: | 7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol |
| Synonyms: | 普林贝瑞; ERB-041 |
| 分子量: | 271.24 |
| 分子式: | C₁₅H₁₀FNO₃ |
| SMILES: | OC1=CC(C=C)=C(OC(C2=CC=C(O)C(F)=C2)=N3)C3=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Prinaberel (ERB-041) 是一种有效的选择性雌激素受体 β (ERβ) 激动剂，对人，大鼠和小鼠 ERβ 的IC50分别为 5.4、3.1 和 3.7 nM。 Prinaberel 对 ERβ 的选择性是 ERα 的 200 倍以上。Prinaberel是有效的皮肤癌化学预防剂，可通过抑制WNT/β-catenin信号通路发挥作用。Prinaberel 诱导卵巢癌细胞凋亡 (apoptosis)。 |
| IC50和靶点: | [{name:"hERβ:5.4 nM (IC50)"},{name: "rat ERβ:3.1 nM (IC50)"},{name: "mouse ERβ:3.7 nM (IC50)"},{name: "hERα:1200 nM (IC50)"},{name: "mouse ERα:750 nM (IC50)"},{name: "rat ERα:620 nM (IC50)"}] |
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Harris, H.A., Albert, L.M., Leathurby, Y., et al.Evaluation of an estrogen receptor-β agonist in animal models of human diseaseEndocrinology144(10),4241-4249(2003)
Harris, H.A., Bruner-Tran, K.L., Zhang, X., et al.A selective estrogen receptor-β agonist causes lesion regression in an experimentally induced model of endometriosisHum. Reprod.20(4),936-941(2005)
