BML-284
Cat. No.：YN450130
CAS No. ：853220-52-7
规格
价格(RMB)
库存
| 产品名称: | BML-284 |
| CAS No.: | 853220-52-7 |
| Chemical Name: | N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine |
| Synonyms: | Wnt agonist 1 |
| 分子量: | 350.37 |
| 分子式: | C₁₉H₁₈N₄O₃ |
| SMILES: | NC1=NC(C2=CC=CC(OC)=C2)=CC(NCC3=CC=C(OCO4)C4=C3)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BML-284 是一种有效的细胞通透性Wnt信号激活剂。BML-284 诱导 TCF 依赖的转录活性，其EC50>700 nM 。 |
| IC50和靶点: | |
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Liu, J., Wu, X., Mitchell, B., et al.A small-molecule agonist of the Wnt signaling pathwayAgnew. Chem. Int. Ed. Engl.44(13),1987-1990(2005)
Lim, J.C., Kania, K.D., Wijesuriya, H., et al.Activation of β-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cellsJ. Neurochem.106(4),1855-1865(2008)
Kuncewitch, M., Yang, W.-L., Corbo, L., et al.WNT agonist decreases tissue damage and improves renal function after ischemia-reperfusionShock43(3),268-275(2015)
