PD-161570
Cat. No.：YN340003
| 产品名称: | PD-161570 |
| CAS No.: | 192705-80-9 |
| Chemical Name: | N-[6-(2,6-dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea |
| Synonyms: | PD 161570 |
| 分子量: | 532.51 |
| 分子式: | C₂₆H₃₅Cl₂N₇O |
| SMILES: | O=C(NC(C)(C)C)NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C3=C(Cl)C=CC=C3Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD-161570 是一种有效的且具有 ATP 竞争能力的人FGF-1受体抑制剂，IC50为 39.9 nM，Ki为 42 nM。PD-161570 还抑制PDGFR，EGFR和c-Src酪氨酸激酶，IC50值分别为 310 nM，240 nM 和 44 nM。PD-161570 抑制PDGF刺激的自磷酸化和FGF-1受体磷酸化，IC50分别为 450 nM 和 622 nM。PD-161570 还是一种骨形态发生蛋白 (BMPs) 和TGF-β信号抑制剂。 |
| IC50和靶点: | [{name:"FGFR1:39.9 nM (IC50)"},{name: "FGFR1:42 nM (Ki)"},{name: "FGFR1 autophosphorylation:622 nM (IC50)"},{name: "PDGFRβ:262 nM (IC50)"},{name: "PDGFR:310 nM (IC50)"},{name: "EGFR:240 nM (IC50)"},{name: "c-Src:44 nM (IC50)'}, 'TGF-β Receptor'] |
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Batley, B.L., Doherty, A.M., Hamby, J.M., et al.Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitorLife Sci.62(2),143-150(1998)
