Tyrphostin AG 528
Cat. No.：YN340008
CAS No. ：133550-49-9
| 产品名称: | Tyrphostin AG 528 |
| CAS No.: | 133550-49-9 |
| Chemical Name: | αE-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-β-oxo-1H-indole-1-propanenitrile |
| Synonyms: | Tyrphostin B66; AG 528 |
| 分子量: | 306.32 |
| 分子式: | C₁₈H₁₄N₂O₃ |
| SMILES: | O=C(/C(C#N)=C/C1=CC=C(O)C(O)=C1)N2CCC3=CC=CC=C32 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tyrphostin AG-528 (Tyrphostin B66) 是一种蛋白酪氨酸激酶抑制剂，对表皮生长因子受体 (EGFR) 的IC50为 4.9 μM，对ErbB2的IC50为 2.1 μM。Tyrphostin AG-528 也是一种抗癌剂。 |
| IC50和靶点: | [{name:"EGFR:4.9 μM (IC50)"},{name: "ErbB2:2.1 μM (IC50)"}] |
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Gazit, A., Osherov, N., Posner, I., et al.Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinasesJ. Med. Chem.34(6),1896-1907(1991)
Leonardi, R., Zhang, Y.-M., Yun, M.-K., et al.Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domainChem. Biol.17(8),892-902(2010)
