AG-494
Cat. No.：YN340021
CAS No. ：133550-35-3
| 产品名称: | AG-494 |
| CAS No.: | 133550-35-3 |
| Chemical Name: | 2E-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide |
| Synonyms: | Tyrphostin AG 494 |
| 分子量: | 280.28 |
| 分子式: | C₁₆H₁₂N₂O₃ |
| SMILES: | O=C(NC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AG-494 (Tyrphostin AG 494) 是一种高效、选择性的EGFR酪氨酸激酶抑制剂 (IC50=0.7 μM)。AG-494 抑制EGFR、ErbB2、HER1-2 和 PDGF-R 的自磷酸化，IC50为 1.1，39，45 和 6 μM。AG-494 阻断 Cdk2 的激活并抑制 EGF 依赖的 DNA 合成。 |
| IC50和靶点: | [{name:"EGFR:0.7 μM (IC50)"}] |
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Gazit, A., Yaish, P., Gilon, C., et al.Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitorsJ. Med. Chem.32(10),2344-2352(1989)
Sagara, Y., Ishige, K., Tsai, C., et al.Tyrphostins protect neuronal cells from oxidative stressJ. Biol. Chem.277(39),36204-36215(2002)
