NSC 228155
Cat. No.：YN340022
CAS No. ：113104-25-9
| 产品名称: | NSC 228155 |
| CAS No.: | 113104-25-9 |
| Chemical Name: | 4-nitro-7-[(1-oxido-2-pyridinyl)thio]-2,1,3-benzoxadiazole |
| Synonyms: | NSC228155 |
| 分子量: | 290.25 |
| 分子式: | C₁₁H₆N₄O₄S |
| SMILES: | [O-][N+]1=CC=CC=C1SC2=CC=C([N+]([O-])=O)C3=NON=C32 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NSC 228155 为EGFR激活剂，可与EGFR的胞外区域结合，诱导EGFR的磷酸化。NSC 228155 是一种有效的KIX-KID相互作用抑制剂，能够抑制CREB的激酶诱导结构域 (KID) 和 KIX (KID 相互作用结构域，来自CBP) 的相互作用，IC50值为 0.36 μM。 |
| IC50和靶点: | |
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Sakanyan, V., Angelini, M., Le Béchec, M., et al.Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cellsSci. Rep.4:3977,(2014)
Xie, F., Li, B.X., Broussard, C., et al.Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcriptionBioorg. Med. Chem. Lett.23(19),5371-5375(2013)
Tholander, F., and Sjöberg, B.-M.Discovery of antimicrobial ribonucleotide reductase inhibitors by screening in microwell formatProc. Natl. Acad. Sci. USA109(25),9798-9803(2012)
