CUDC-101
Cat. No.：YN340034
CAS No. ：1012054-59-9
| 产品名称: | CUDC-101 |
| CAS No.: | 1012054-59-9 |
| Chemical Name: | 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy-heptanamide |
| Synonyms: | CUDC 101,CUDC101 |
| 分子量: | 434.49 |
| 分子式: | C₂₄H₂₆N₄O₄ |
| SMILES: | C#CC1=CC=CC(NC2=NC=NC3=CC(OC)=C(C=C23)OCCCCCCC(NO)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CUDC-101 是一种高效的HDAC、EGFR和HER2抑制剂，对应的IC50值分别为 4.4、2.4 和 15.7 nM。 |
| IC50和靶点: | [{name:"EGFR:2.4 nM (IC50)"},{name: "HER2:15.7 nM (IC50)"},{name: "HDAC:4.4 nM (IC50)"},{name: "HDAC1:4.5 nM (IC50)"},{name: "HDAC2:12.6 nM (IC50)"},{name: "HDAC3:9.1 nM (IC50)"},{name: "HDAC4:13.2 nM (IC50)"},{name: "HDAC6:5.1 nM (IC50)"},{name: "HDAC5:11.4 nM (IC50)"},{name: "HDAC9:67.2 nM (IC50)"},{name: "HDAC10:26.1 nM (IC50)"},{name: "HDAC8:79.8 nM (IC50)"},{name: "HDAC7:373 nM (IC50)"}] |
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Lai, C.J., Bao, R., Tao, W., et al.CUDC-101, a multitargeted inhibitor of histone deacetylase, epidermal growth factor receptor, and human epidermal growth factor receptor 2, exerts potent anticancer activityCancer Res.70(9),3647-3656(2010)
Wang, J., Pursell, N.W., Samson, M.E.S., et al.Potential advantages of CUDC-101, a multitargeted HDAC, EGFR, and HER2 inhibitor, in treating drug resistance and preventing cancer cell migration and invasionMol. Cancer Ther.12(6),925-936(2013)
