CL-387785
Cat. No.：YN340041
CAS No. ：194423-06-8
| 产品名称: | CL-387785 |
| CAS No.: | 194423-06-8 |
| Chemical Name: | N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide |
| Synonyms: | EKI-785; WAY-EKI 785 |
| 分子量: | 381.23 |
| 分子式: | C₁₈H₁₃BrN₄O |
| SMILES: | O=C(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)C#CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CL-387785 (EKI785; WAY-EKI 785) 是一种不可逆的EGFR抑制剂，IC50为 370 pM。 |
| IC50和靶点: | [{name:"EGFR:370 pM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Sausville, E.A., Elsayed, Y., Monga, M., et al.Signal transduction-directed cancer treatmentsAnnu. Rev. Pharmacol. Toxicol.43,199-231(2003)
Discafani, C.M., Carroll, M.L., Floyd, M.B., Jr., et al.Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785)Biochem. Pharmacol.57(8),917-925(1999)
