AV-412
Cat. No.：YN340045
| 产品名称: | AV-412 |
| CAS No.: | 451493-31-5 |
| Chemical Name: | N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-2-propenamide, 4-methylbenzenesulfonate (1:2) |
| Synonyms: | MP412 |
| 分子量: | 851.41 |
| 分子式: | C₄₁H₄₄ClFN₆O₇S₂ |
| SMILES: | O=S(C1=CC=C(C)C=C1)(O)=O.C=CC(NC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2C#CC(N5CCN(C)CC5)(C)C)=O.O=S(C6=CC=C(C)C=C6)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AV-412 (MP412) 是EGFR抑制剂，抑制EGFR，EGFRL858R，EGFRT790M，EGFRL858R/T790M和 ErbB2的IC50值分别为0.75，0.5，0.79，2.3，19 nM。 |
| IC50和靶点: | [{name:"EGFR:0.75 nM (IC50)"},{name: "EGFRL858R:0.5 nM (IC50)"},{name: "EGFRT790M:0.79 nM (IC50)"},{name: "EGFRL858R/T790M:2.3 nM (IC50)"},{name: "ErbB2:19 nM (IC50)"}] |
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Suzuki, T., Fujii, A., Ohya, J., et al.Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptor and ErbB2 tyrosine kinase inhibitorCancer Sci.98(12),1977-1984(2007)
Suzuki, T., Fujii, A., Ochi, H., et al.Ubiquitination and downregulation of ErbB2 and estrogen receptor-alpha by kinase inhibitor MP-412 in human breast cancer cellsJ. Cell. Biochem.112(9),2279-2286(2011)
