Canertinib
Cat. No.：YN340047
CAS No. ：267243-28-7
| 产品名称: | Canertinib |
| CAS No.: | 267243-28-7 |
| Chemical Name: | N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide; N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide; |
| Synonyms: | CI-1033; PD-183805 |
| 分子量: | 485.94 |
| 分子式: | C₂₄H₂₅ClFN₅O₃ |
| SMILES: | O=C(NC1=C(C=C2C(C(NC3=CC=C(C(Cl)=C3)F)=NC=N2)=C1)OCCCN4CCOCC4)C=C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Canertinib (CI-1033;PD-183805) 是有效地，不可逆的EGFR抑制剂；抑制细胞EGFR和ErbB2自身磷酸化的IC50值分别为7.4和9 nM。 |
| IC50和靶点: | [{name:"EGFR:7.4 nM (IC50)"},{name: "ErbB2:9 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Li, D., et al.: Oncogene, 27, 4702 (2008), Brown, A., et al.: Toxicol. Pathol., 36, 410 (2008), Chen, H., et al.: Chem. Biol. Drug Design, 71, 434 (2008),
