Canertinib dihydrochloride
Cat. No.：YN340048
CAS No. ：289499-45-2
| 产品名称: | Canertinib dihydrochloride |
| CAS No.: | 289499-45-2 |
| Chemical Name: | N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide, dihydrochloride |
| Synonyms: | CI-1033 dihydrochloride; PD-183805 dihydrochloride |
| 分子量: | 558.86 |
| 分子式: | C₂₄H₂₇Cl₃FN₅O₃ |
| SMILES: | C=CC(NC1=CC2=C(N=CN=C2C=C1OCCCN3CCOCC3)NC4=CC=C(C(Cl)=C4)F)=O.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Canertinib dihydrochloride (CI-1033;PD-183805) 是有效地，不可逆的EGFR抑制剂；抑制细胞EGFR和ErbB2自身磷酸化的IC50值分别为 7.4和 9 nM。 |
| IC50和靶点: | [{name:"EGFR:7.4 nM (IC50)"},{name: "ErbB2:9 nM (IC50)"}] |
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| Solvent & Solubility: |
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Richards, K.N., Zweidler-McKay, P.A., Van Roy, N., et al.Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivoCancer116(13),3233-3243(2010)
Nordigården, A., Zetterblad, J., Trinks, C., et al.Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in miceBr. J. Haematol.155,198-208(2011)
Erlichman, C., Boerner, S.A., Hallgren, C.G., et al.The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug effluxCancer Res.61,739-748(2001)
