Theliatinib
Cat. No.：YN340053
CAS No. ：1353644-70-8
| 产品名称: | Theliatinib |
| CAS No.: | 1353644-70-8 |
| Chemical Name: | |
| Synonyms: | 西利替尼; HMPL-309 |
| 分子量: | 442.51 |
| 分子式: | C₂₅H₂₆N₆O₂ |
| SMILES: | O=C(N1C[C@]2([H])N(C)CC[C@]2([H])C1)NC3=CC4=C(NC5=CC=CC(C#C)=C5)N=CN=C4C=C3OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Theliatinib (HMPL-309) 是一种有效、ATP 竞争性、口服活性和高度选择性的EGFR抑制剂，Ki为 0.05 nM，IC50为 3 nM。Theliatinib 对EGFR T790M/L858R突变体的IC50值为 22 nM。Theliatinib 对EGFR的选择性是其他激酶的 50 倍以上。抗肿瘤活性。 |
| IC50和靶点: | [{name:"EGFR:3 nM (IC50)"},{name: "EGFR:0.05 nM (Ki)"},{name: "EGFR (L858R/T790M):22 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
