Varlitinib
Cat. No.：YN340058
CAS No. ：845272-21-1
| 产品名称: | Varlitinib |
| CAS No.: | 845272-21-1 |
| Chemical Name: | N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-4,6-quinazolinediamine |
| Synonyms: | ASLAN001; ARRY-334543 |
| 分子量: | 466.94 |
| 分子式: | C₂₂H₁₉ClN₆O₂S |
| SMILES: | C[C@H]1N=C(NC2=CC3=C(NC4=CC=C(OCC5=NC=CS5)C(Cl)=C4)N=CN=C3C=C2)OC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Varlitinib (ASLAN001) 是有效，可逆的泛EGFR小分子抑制剂，对 HER1，HER2 和 HER4 的IC50值分别为7，2，4 nM。 |
| IC50和靶点: | [{name:"HER1:7 nM (IC50)"},{name: "HER2:2 nM (IC50)"},{name: "HER4:4 nM (IC50)"}] |
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| Solvent & Solubility: |
Miknis, G., Wallace, E., Lyssikatos, J., et al.ARRY-334543, a potent, orally active, small molecule inhibitor of EGFR and ErbB-2Cancer Res.65(9 Suppl.),801(2005)
Liu, C.-Y., Chu, P.-Y., Huang, C.-T., et al.Varlitinib downregulates HER/ERK signaling and induces apoptosis in triple negative breast cancer cellsCancer (Basel)11(1),E105(2019)
