PD-089828
Cat. No.：YN340077
| 产品名称: | PD-089828 |
| CAS No.: | 179343-17-0 |
| Chemical Name: | N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea |
| Synonyms: | |
| 分子量: | 405.28 |
| 分子式: | C₁₈H₁₈Cl₂N₆O |
| SMILES: | O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=C(Cl)C=CC=C3Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD-089828 是 ATP 竞争性FGFR-1、PDGFR-β和EGFR(IC50分别为 0.15, 1.76, 5.47 µM) 抑制剂和c-Src酪氨酸激酶非竞争性抑制剂 (IC50=0.18 µM)。PD-089828 也抑制MAPK，IC50值为 7.1 µM。PD-089828 体外抑制 PDGF-、EGF- 和 bFGF 介导的酪氨酸激酶受体的自磷酸化。PD-089828 具有持久的细胞活性。 |
| IC50和靶点: | [{name:"FGFR1:0.15 μM (IC50)"},{name: "PDGFR-β:1.76 μM (IC50)"},{name: "EGFR:5.47 μM (IC50)"},{name: "c-Src:0.18 μM (IC50)"},{name: "FGFR1:0.14 μM (Ki)"},{name: "PDGFR-β:2.38 μM (Ki)"},{name: "EGFR:3.16 μM (Ki)"},{name: "c-Src:0.1 μM (Ki)"}] |
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| Solvent & Solubility: |
Dahring, T.K., Lu, G.H., Hamby, J.M., et al.Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitorJ. Pharmacol. Exp. Ther.281(3),1446-1456(1997)
