Almonertinib hydrochloride
Cat. No.：YN340082
CAS No. ：2134096-03-8
| 产品名称: | Almonertinib hydrochloride |
| CAS No.: | 2134096-03-8 |
| Chemical Name: | |
| Synonyms: | 盐酸阿美替尼; HS-10296 hydrochloride |
| 分子量: | 562.11 |
| 分子式: | C₃₀H₃₆ClN₇O₂ |
| SMILES: | COC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Almonertinib (HS-10296) hydrochloride 是一种口服、不可逆的第三代EGFR酪氨酸激酶抑制剂，对 EGFR 致敏和 T790M 耐药突变具有高选择性。Almonertinib hydrochloride 对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性 (IC50分别为 0.37、0.29 和 0.21 nM)，对野生型的抑制作用较弱 (3.39 nM)。Almonertinib hydrochloride 用于非小细胞肺癌的研究。 |
| IC50和靶点: | [{name:"EGFRT790M:0.37 nM (IC50)"},{name: "EGFRL858R/T790M:0.29 mM (IC50)"},{name: "EGFRdel19 T790M:0.214 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
