WZ-3146
Cat. No.：YN340090
CAS No. ：1214265-56-1
| 产品名称: | WZ-3146 |
| CAS No.: | 1214265-56-1 |
| Chemical Name: | N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide |
| Synonyms: | WZ 3146,WZ-3146 |
| 分子量: | 464.95 |
| 分子式: | C₂₄H₂₅ClN₆O₂ |
| SMILES: | CN1CCN(C2=CC=C(C=C2)NC3=NC=C(C(OC4=CC(NC(C=C)=O)=CC=C4)=N3)Cl)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WZ3146是突变选择性的EGFR抑制剂；对EGFRL858R，EGFRL858R/T790M，EGFRE746_A750，EGFRE746_A750/T790Mand EGFR 的IC50值分别为2，2，5，14 和 66 nM。 |
| IC50和靶点: | [{name:"EGFRL858R:2 nM (IC50)"},{name: "EGFRL858R/T790M:5 nM (IC50)"},{name: "EGFRE746_A750:2 nM (IC50)"},{name: "EGFRE746_A750/T790M:14 nM (IC50)"},{name: "EGFR:24 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Zhou, W., Ercan, D., Chen, L., et al.Novel mutant-selective EGFR kinase inhibitors against EGFR T790MNature462(7276),1070-1074(2009)
Zhou, W., Ercan, D., Jänne, P.A., et al.Discovery of selective irreversible inhibitors for EGFR-T790MBioorg. Med. Chem. Lett.21(2),638-643(2011)
