Erlotinib D6 hydrochloride
Cat. No.：YN340093
| 产品名称: | Erlotinib D6 hydrochloride |
| CAS No.: | 1189953-78-3 |
| Chemical Name: | N-(3-ethynylphenyl)-6,7-bis[2-(methoxy-d3)ethoxy]-4-quinazolinamine, monohydrochloride |
| Synonyms: | CP-358774 D6 hydrochloride; NSC 718781 D6 hydrochloride; OSI-774 D6 hydrochloride |
| 分子量: | 435.93 |
| 分子式: | C₂₂H₁₈D₆ClN₃O₄ |
| SMILES: | [2H]C([2H])([2H])OCCOC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCOC([2H])([2H])[2H].[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Erlotinib D6 hydrochloride (CP-358774 D6 hydrochloride) 是 Erlotinib Hydrochloride 的一种氘代化合物。Erlotinib Hydrochloride 抑制 EGFR 激酶的 IC50为 2 nM 。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ciardiello, F., and Tortora, G.A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptorClin. Cancer Res.7(10),2958-2970(2001)
Moyer, J.D., Barbacci, E.G., Iwata, K.K., et al.Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinaseCancer Res.57(21),4838-4848(1997)
Herbst, R.S., and Bunn, P.A., Jr.Targeting the epidermal growth factor receptor in non-small cell lung cancerClin. Cancer Res.9(16),5813-5824(2003)
