PD153035 Hydrochloride
Cat. No.：YN340095
CAS No. ：183322-45-4
| 产品名称: | PD153035 Hydrochloride |
| CAS No.: | 183322-45-4 |
| Chemical Name: | N-(3-bromophenyl)-6,7-dimethoxy-4-quinazolinamine, monohydrochloride |
| Synonyms: | SU-5271 Hydrochloride; AG1517 Hydrochloride; ZM 252868 Hydrochloride |
| 分子量: | 396.67 |
| 分子式: | C₁₆H₁₅BrClN₃O₂ |
| SMILES: | COC1=C(C=C(C2=C1)N=CN=C2NC3=CC(Br)=CC=C3)OC.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD153035 Hydrochloride (SU-5271 Hydrochloride) 是有效地EGFR抑制剂，Ki和IC50值分别为6和25 pM。 |
| IC50和靶点: | [{name:"EGFR:6 pM (Ki)"},{name: "EGFR:25 pM (IC50)"}] |
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| Solvent & Solubility: |
Ciardiello, F., and Tortora, G.A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptorClin. Cancer Res.7(10),2958-2970(2001)
Fry, D.W., Kraker, A.J., McMichael, A., et al.A specific inhibitor of the epidermal growth factor receptor tyrosine kinaseScience265(5175),1093-1095(1994)
Bos, M., Mendelsohn, J., Kim, Y.M., et al.PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent mannerClin. Cancer Res.3(11),2099-2106(1997)
Rae, J.M., and Lippman, M.E.Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitorsBreast Cancer Res. Treat.83(2),99-107(2004)
