Sapitinib
Cat. No.：YN340121
CAS No. ：848942-61-0
| 产品名称: | Sapitinib |
| CAS No.: | 848942-61-0 |
| Chemical Name: | 4-[[4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-methyl-1-piperidineacetamide |
| Synonyms: | 沙普替尼; AZD-8931 |
| 分子量: | 473.93 |
| 分子式: | C₂₃H₂₅ClFN₅O₃ |
| SMILES: | O=C(CN1CCC(OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC)CC1)NC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sapitinib (AZD-8931)是可逆的，ATP竞争型EGFR抑制剂，对EGFR，ErbB2 和 ErbB3的IC50值分别为4，3 和 4 nM。 |
| IC50和靶点: | [{name:"EGFR:4 nM (IC50)"},{name: "ErbB2:3 nM (IC50)"},{name: "HER3:4 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hickinson, D.M., Klinowska, T., Speake, G., et al.AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: A unique agent for simultaneous ERBB receptor blockade in cancerClin. Cancer Res.16(4),1159-1169(2010)
Mu, Z., Klinowska, T., Dong, X., et al.AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: Preclinical activity in HER2 non-amplified inflammatory breast cancer modelsJ. Exp. Clin. Cancer Res.33:47,(2014)
