EGFR-IN-11
Cat. No.：YN340122
CAS No. ：2463200-44-2
| 产品名称: | EGFR-IN-11 |
| CAS No.: | 2463200-44-2 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 573.71 |
| 分子式: | C₂₉H₃₅N₉O₂S |
| SMILES: | CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C=N3)N=C(NC5=CC=CC=C5)N4[C@H]6CN(CC6)S(C7CC7)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EGFR-IN-11 是第四代EGFR-酪氨酸激酶抑制剂 (EGFR-TKI)，对三重突变的EGFRL858R/T790M/C797S的IC50为 18 nM。EGFR-IN-11 显著抑制 EGFR 磷酸化，诱导细胞凋亡，将细胞周期阻滞在 G0/G1处。 |
| IC50和靶点: | [{name:"EGFRL858R/T790M/C797S:18 nM (IC50)"}] |
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