Tesevatinib
Cat. No.：YN340130
| 产品名称: | Tesevatinib |
| CAS No.: | 781613-23-8 |
| Chemical Name: | N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aα,5β,6aα)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-4-quinazolinamine |
| Synonyms: | XL-647; EXEL-7647; KD-019 |
| 分子量: | 491.39 |
| 分子式: | C₂₄H₂₅Cl₂FN₄O₂ |
| SMILES: | [H][C@@]12[C@@](C[C@@H](COC3=CC4=C(C(NC5=C(F)C(Cl)=C(Cl)C=C5)=NC=N4)C=C3OC)C2)([H])CN(C)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tesevatinib (XL-647; EXEL-7647; KD-019) 是口服可用的多靶点酪氨酸激酶抑制剂; 抑制EGFR，ErbB2，KDR，Flt4和EphB4激酶活性的IC50值分别为 0.3，16，1.5，8.7，和1.4 nM。 |
| IC50和靶点: | [{name:"EGFR:0.3 nM (IC50)"},{name: "ErbB2:16 nM (IC50)"},{name: "KDR:1.5 nM (IC50)"},{name: "Flt-4:8.7 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Gendreau, S.B., Ventura, R., Keast, P., et al.Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647Clin. Cancer Res.13(12),3713-3723(2007)
