ZM 449829
Cat. No.:YN340133
CAS No. :4452-06-6
产品名称: | ZM 449829 |
CAS No.: | 4452-06-6 |
Chemical Name: | 1-(2-naphthalenyl)-2-propen-1-one |
Synonyms: | |
分子量: | 182.22 |
分子式: | C₁₃H₁₀O |
SMILES: | C=CC(C1=CC=C2C=CC=CC2=C1)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | ZM 449829 是有效的、选择性和 ATP 竞争性的JAK3抑制剂,pIC50值为 6.8。ZM 449829 是可用于研究JAK3的药理学工具。 |
IC50和靶点: | |
In Vitro: | |
In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Brown, G.R., Bamford, A.M., Bowyer, J., et al.Naphthyl ketones: A new class of Janus kinase 3 inhibitorsBioorg. Med. Chem. Lett.10(6),575-579(2000)
Luo, C., and Laaja, P.Inhibitors of JAKs/STATs and the kinases: A possible new cluster of drugsDrug Discov. Today9(6),268-275(2004)
Lai, T.-S., Liu, Y., Tucker, T., et al.Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug librariesChem. Biol.15(9),969-978(2008)
Choi, H.S., Kim, D.-A., Chung, H., et al.Screening of breast cancer stem cell inhibitors using a protein kinase inhibitor libraryCancer Cell Int.17,25(2017)
Hussain, S.K., Broederdorf, L.J., Sharma, U.M., et al.Host kinase activity is required for Coxiella burnetii parasitophorous vacuole formationFront. Microbiol.1,137(2010)