AG-1478
Cat. No.：YN340135
CAS No. ：153436-53-4
| 产品名称: | AG-1478 |
| CAS No.: | 153436-53-4 |
| Chemical Name: | N-(3-chlorophenyl)-6,7-dimethoxy-4-quinazolinamine |
| Synonyms: | NSC 693255 |
| 分子量: | 315.75 |
| 分子式: | C₁₆H₁₄ClN₃O₂ |
| SMILES: | COC1=CC2=NC=NC(NC3=CC=CC(Cl)=C3)=C2C=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AG-1478 (Tyrphostin AG-1478) 是一种选择性的EGFR酪氨酸激酶抑制剂，IC50为 3 nM。AG-1478 对HCV和脑心肌炎病毒 (EMCV) 具有抗病毒作用。 |
| IC50和靶点: | [{name:"EGFR:3 nM (IC50)'}, 'HCV', 'EMCV'] |
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| Solvent & Solubility: |
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Choi, B.H., Choi, J.S., Rhie, D.J., et al.Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitorAm. J. Physiol. Cell Physiol.282,c1461-c1468(2002)
Shushan, A., Rojansky, N., Laufer, N., et al.The AG1478 tyrosine kinase inhibitor is an effective suppressor of leiomyoma cell growthHum. Reprod.19(9),1957-1967(2004)
Daub, H., Weiss, F.U., Wallasch, C., et al.Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptorsNature379,557-560(1996)
