Mobocertinib
Cat. No.：YN340140
CAS No. ：1847461-43-1
| 产品名称: | Mobocertinib |
| CAS No.: | 1847461-43-1 |
| Chemical Name: | 2-[[4-[[2-(dimethylamino)ethyl]methylamino]-2-methoxy-5-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-4-(1-methyl-1H -indol-3-yl)-5-pyrimidinecarboxylic acid, 1-methylethyl ester |
| Synonyms: | TAK-788; AP32788 |
| 分子量: | 585.70 |
| 分子式: | C₃₂H₃₉N₇O₄ |
| SMILES: | O=C(C1=CN=C(NC2=CC(NC(C=C)=O)=C(N(CCN(C)C)C)C=C2OC)N=C1C3=CN(C)C4=C3C=CC=C4)OC(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mobocertinib (TAK-788) 是一种有效的的，具有口服活性的EGFR和HER2突变的抑制剂，包括外显子 20 的插入，并且选择性高于 WT EGFR。具有抗肿瘤活性。 |
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Chouitar, J., Vincent, S., Brake, R., et al.TAK-788 is a novel and potent tyrosine kinase inhibitor with selective activity against EGFR/HER2AbstractsS811,P2(13-32)(2018)
Neal, J., Doebele, R., Riely, G., et al.Safety, PK, and preliminary antitumor activity of the oral EGFR/HER2 exon 20 inhibitor TAK-788 in NSCLCAbstractsS599,P1(13-44)(2018)
