Chrysophanol
Cat. No.：YN340143
| 产品名称: | Chrysophanol |
| CAS No.: | 481-74-3 |
| Chemical Name: | 1,8-dihydroxy-3-methyl-9,10-anthracenedione |
| Synonyms: | 大黄酚; Chrysophanic acid |
| 分子量: | 254.24 |
| 分子式: | C₁₅H₁₀O₄ |
| SMILES: | O=C1C2=C(C=CC=C2O)C(C3=CC(C)=CC(O)=C13)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Chrysophanol (Chrysophanic acid) 是一种天然蒽醌，抑制EGF-诱导的EGFR磷酸化，且抑制AKT和mTOR/p70S6K激活。 |
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Qi, F.H., Wang, Z.X., Cai, P.P., et al.Traditional Chinese medicine and related active compounds: A review of their role on hepatitis B virus infectionDrug Discov. Ther.7(6),212-224(2013)
Lu, C.-C., Yang, J.-S., Huang, A.-C., et al.Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cellsMol. Nutr. Food Res.54(7),967-976(2010)
Lin, F., Zhang, C., Chen, X., et al.Chrysophanol affords neuroprotection against microglial activation and free radical-mediated oxidative damage in BV2 murine microgliaInt. J. Clin. Exp. Med.8(3),3447-3455(2015)
Kim, S.-J., Kim, M.-C., Lee, B.-J., et al.Anti-inflammatory activity of chrysophanol through the suppression of NF-κB/caspase-1 activation in vitro and in vivoMolecules15(9),6436-6451(2010)
Zhao, Y., Fang, Y., Li, J., et al.Neuroprotective effects of chrysophanol against inflammation in middle cerebral artery occlusion miceNeurosci. Lett.630,16-22(2016)
