BDTX-189
Cat. No.：YN340146
CAS No. ：2414572-47-5
| 产品名称: | BDTX-189 |
| CAS No.: | 2414572-47-5 |
| Chemical Name: | N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-[2-(4-morpholinyl)ethoxy]-6-quinazolinyl]-2-propenamide |
| Synonyms: | BDTX-189 |
| 分子量: | 561.03 |
| 分子式: | C₂₉H₂₉ClN₆O₄ |
| SMILES: | C=CC(NC1=CC2=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)N=CN=C2C=C1OCCN5CCOCC5)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BDTX-189 是一种高效的具有口服活性的选择性EGFR、HER2变构突变抑制剂，包括 EGFR/HER2 外显子 20 插入突变。BDTX-189 对 EGFR、HER2、BLK 和 RIPK2 的KD值分别显示 0.2、0.76、13 和 1.2 nM。具有抗癌活性。 |
| IC50和靶点: | [{name:"EGFR:0.2 nM (Kd)"},{name: "HER2:0.76 nM (Kd)"},{name: "RIPK2:1.2 nM (Kd)"},{name: "BLK:13 nM (Kd)"}] |
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| Solvent & Solubility: |
Flohr, A., Mayweg, A., Trainor, G., et al.Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use,(2020)
