PD168393
Cat. No.：YN340151
CAS No. ：194423-15-9
| 产品名称: | PD168393 |
| CAS No.: | 194423-15-9 |
| Chemical Name: | N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-propenamide |
| Synonyms: | PD168393,PD-168393,PD 168393 |
| 分子量: | 369.22 |
| 分子式: | C₁₇H₁₃BrN₄O |
| SMILES: | C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD168393 是有效、选择性和细胞渗透性的 EGFR 酪氨酸激酶 (EGFR tyrosine kinase) 和ErbB2的抑制剂。PD168393 不可逆转地失活 EGF 受体 (IC50=0.7 nM)，但对胰岛素受体、PDGFR、FGFR 和 PKC 无作用。 |
| IC50和靶点: | [{name:"EGFR:0.7 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Fry, D.W., Kraker, A.J., McMichael, A., et al.A specific inhibitor of the epidermal growth factor receptor tyrosine kinaseScience265(5175),1093-1095(1994)
Pulit-Penaloza, J.A., Sapkota, B., Esser, E.S., et al.Modulation of influenza vaccine immune responses using an epidermal growth factor receptor kinase inhibitorSci. Rep.5,12321(2015)
Sun, X., Liang, J., Yao, X., et al.The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemiaOncotarget6(34),35478-35495(2015)
Wang, S.H., Wang, S.C., Chen, P.C., et al.Induction of cyclooxygenase-2 gene by Candida albicans through EGFR, ERK, and p38 pathways in human urinary epitheliumMed. Mycol.Epub ahead of print,(2016)
