CNX-2006
Cat. No.：YN340152
CAS No. ：1375465-09-0
| 产品名称: | CNX-2006 |
| CAS No.: | 1375465-09-0 |
| Chemical Name: | N-[3-[[2-[[4-[[1-(2-fluoroethyl)-3-azetidinyl]amino]-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide |
| Synonyms: | CNX 2006,CNX2006 |
| 分子量: | 545.53 |
| 分子式: | C₂₆H₂₇F₄N₇O₂ |
| SMILES: | C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(NC4CN(CCF)C4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CNX-2006是不可逆的EGFR突变体抑制剂；对 EGFRT790M的IC50值小于20 nM。 |
| IC50和靶点: | [{name:"EGFRT790M:20 nM (IC50)'}, 'EGFRL858R/T790M'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Galvani, E., Sun, J., Leon, L.G., et al.NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitorOncotarget6(40),42717-42732(2015)
