Genistein
Cat. No.：YN340158
| 产品名称: | Genistein |
| CAS No.: | 446-72-0 |
| Chemical Name: | 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Synonyms: | 染料木素; NPI 031L |
| 分子量: | 270.24 |
| 分子式: | C₁₅H₁₀O₅ |
| SMILES: | OC1=C2C(OC=C(C3=CC=C(O)C=C3)C2=O)=CC(O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Genistein是一种大豆异黄酮，是一种多重的酪氨酸激酶 (tyrosine kinases，比如EGFR) 抑制剂，是对多种癌症的化疗剂，主要通过改变细胞凋亡 (apoptosis)，细胞周期和血管生成以及抑制转移。 |
| IC50和靶点: | [{name:"EGFR:0.6 μM (IC50, Cell Assay)"}] |
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Spagnuolo, C., Russo, G.L., Orhan, I.E., et al.Genistein and cancer: Current status, challenges, and future directionsAdv. Nutr.6(4),408-419(2015)
Akiyama, T., Ishida, J., Nakagawa, S., et al.Genistein, a specific inhibitor of tyrosine-specific protein kinasesJ. Biol. Chem.262(1),5592-5595(1987)
Gu, Y., Zhu, C.-F., Iwamoto, H., et al.Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesisWorld J. Gastroenterol.11(41),6512-6517(2005)
Newbold, R.R., Banks, E.P., Bullock, B., et al.Uterine adenocarcinoma in mice treated neonatally with genisteinCancer Res.61(11),4325-4328(2001)
Pummoung, S., Werawatganon, D., Klaikeaw, N., et al.Genistein-attenuated hepatic steatosis and inflammation in nonalcoholic steatohepatitis with bilateral ovariectomized ratsPharmacogn. Mag.14(55),20-24(2018)
Guo, J., Xu, X., Rasheed, T.K., et al.Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cellsRetrovirology10,62(2013)
