CP-724714
Cat. No.：YN340159
CAS No. ：383432-38-0
| 产品名称: | CP-724714 |
| CAS No.: | 383432-38-0 |
| Chemical Name: | 2-methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-acetamide |
| Synonyms: | CP724714,CP 724714 |
| 分子量: | 469.53 |
| 分子式: | C₂₇H₂₇N₅O₃ |
| SMILES: | O=C(COC)NC/C=C/C1=CC2=C(N=CN=C2C=C1)NC3=CC=C(C(C)=C3)OC4=CC=C(N=C4)C.[(E)] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CP-724714 是一种高效、选择性口服活性的ErbB2 (HER2)酪氨酸激酶抑制剂，IC50为 10 nM。CP-724714 对 EGFR 激酶有明显的选择性 (IC50=6400 nM)。CP-724714 能抑制完整细胞中 ErbB2 受体的自磷酸化。具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"ErbB2:10 nM (IC50)"}] |
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| Solvent & Solubility: |
Jani, J.P., Finn, R.S., Campbell, M., et al.Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitorCancer Res.67(20),9887-9893(2007)
Feng, B., Xu, J.J., Bi, Y.A., et al.Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714Toxicol. Sci.108(2),492-500(2009)
