Rociletinib
Cat. No.：YN340180
CAS No. ：1374640-70-6
| 产品名称: | Rociletinib |
| CAS No.: | 1374640-70-6 |
| Chemical Name: | N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-2-propenamide |
| Synonyms: | CO-1686; AVL-301; CNX-419 |
| 分子量: | 555.55 |
| 分子式: | C₂₇H₂₈F₃N₇O₃ |
| SMILES: | C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rociletinib (CO-1686) 是一种可口服的EGFR抑制剂，能够抑制 EGFRL858R/T790M 和 EGFRWT 的活性，IC50值分别为 21.5 nM 和 303.3 nM。 |
| IC50和靶点: | [{name:"EGFRL858R/T790M:21.5 nM (Ki)"},{name: "EGFRT790M:303.3 nM (Ki)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Walter, A.O., Sjin, R.T.T., Haringsma, H.J., et al.Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLCCancer Discov.3(12),1404-1415(2013)
