WHI-P180
Cat. No.：YN340183
| 产品名称: | WHI-P180 |
| CAS No.: | 211555-08-7 |
| Chemical Name: | 3-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol |
| Synonyms: | Janex 3 |
| 分子量: | 297.31 |
| 分子式: | C₁₆H₁₅N₃O₃ |
| SMILES: | COC1=CC2=NC=NC(NC3=CC=CC(O)=C3)=C2C=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WHI-P180 (Janex 3)是多种激酶抑制剂；抑制RET，KDR和EGFR的IC50值分别为5 nM，66 nM 和4 μM。 |
| IC50和靶点: | [{name:"EGFR:4 μM (IC50)"},{name: "KDR:66 nM (IC50)"},{name: "RET:5 nM (IC50)"}] |
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Newton, R., Bowler, K.A., Burns, E.M., et al.The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivityEur. J. Med. Chem.13,20-32(2016)
Ghosh, S., Jennissen, J.D., Liu, X.P., et al.4-[3-Bromo-4-hydroxyphenyl)amino]-6,7-dimethoxyquinazolin-1-ium chloride methanol solvate and 4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chlorideActa. Crystallogr. C.57(Pt 1),76-78(2001)
Xue, Y., Wan, P.T., Hillertz, P., et al.X-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitorsChemMedChem8(11),1846-1854(2013)
Cetkovic-Cvrlje, M., Roers, B.A., Schonhoff, D., et al.Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitorLeuk. Lymphoma.43(7),1447-1453(2002)
Chen, C.-L., Malaviya, R., Navara, C., et al.Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4-(3-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in micePharm. Res.16(1),117-122(1999)
