Osimertinib
Cat. No.：YN340185
CAS No. ：1421373-65-0
| 产品名称: | Osimertinib |
| CAS No.: | 1421373-65-0 |
| Chemical Name: | N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide |
| Synonyms: | 奥希替尼; AZD-9291; Mereletinib |
| 分子量: | 499.61 |
| 分子式: | C₂₈H₃₃N₇O₂ |
| SMILES: | C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Osimertinib (AZD-9291) 是一种不可逆和突变的选择性的EGFR抑制剂，抑制EGFRL858R和EGFRL858R/T790M的IC50分别为12 和 1 nM。 |
| IC50和靶点: | [{name:"EGFRL858R:12 nM (IC50, Enzyme assays)"},{name: "EGFRL858R/T790M:1 nM (IC50, Enzyme assays)"}] |
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Cross, D.A.E., Ashton, S.E., Ghiorghiu, S., et al.AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancerCancer Discov.4(9),1046-1061(2014)
