AG-825
Cat. No.：YN340187
CAS No. ：149092-50-2
| 产品名称: | AG-825 |
| CAS No.: | 149092-50-2 |
| Chemical Name: | 3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide |
| Synonyms: | Tyrphostin AG 825; Tyrphostin AG-825; Tyrphostin AG825. |
| 分子量: | 397.47 |
| 分子式: | C₁₉H₁₅N₃O₃S₂ |
| SMILES: | O=C(N)/C(C#N)=C/C1=CC(OC)=C(O)C(CSC2=NC3=CC=CC=C3S2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AG-825 是一种选择性、ATP竞争性，抑制酪氨酸磷酸化的ErbB2抑制剂，其IC50值为 0.35 μM。AG-825 具有抗癌活性。AG825 能明显加速人中性粒细胞的凋亡。AG-825 是一种潜在的克服锰诱导的神经毒性或阿尔茨海默病发展的药物。 |
| IC50和靶点: | [{name:"ErbB2:0.35 μM (IC50)"},{name: "EGFR:19 μM (IC50)"}] |
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Reese, D.M., and Slamon, D.J.HER-2/neu signal transduction in human breast and ovarian cancerStem Cells15,1-8(1997)
Osherov, N., Gazit, A., Gilon, C., et al.Selective inhibition of the epidermal growth factor and HER2/Neu receptors by tyrphostinsJ. Biol. Chem.268(15),11134-11142(1993)
Murillo, H., Schmidt, L.J., and Tindall, D.J.Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-2Cancer Res.61,7408-7412(2001)
