FIIN-3
Cat. No.：YN340210
CAS No. ：1637735-84-2
| 产品名称: | FIIN-3 |
| CAS No.: | 1637735-84-2 |
| Chemical Name: | N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-2-propenamide |
| Synonyms: | FIIN-3;FIIN 3 |
| 分子量: | 691.61 |
| 分子式: | C₃₄H₃₆Cl₂N₈O₄ |
| SMILES: | C=CC(NC1=CC=C(CN(C(NC2=C(Cl)C(OC)=CC(OC)=C2Cl)=O)C3=NC=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=C3)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FIIN-3 是FGFR的不可逆抑制剂，对FGFR1，FGFR2，FGFR3和FGFR4的IC50值分别为13.1，21，31.4和35.3 nM。 |
| IC50和靶点: | [{name:"FGFR1:13.1 nM (IC50)"},{name: "FGFR2:21 nM (IC50)"},{name: "FGFR3:31.4 nM (IC50)"},{name: "FGFR4:35.3 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Tan, L., Wang, J., Tanizaki, J., et al.Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitorsProc. Natl. Acad. Sci. USA111(45),E4869-E4877(2014)
