PD158780
Cat. No.：YN340211
| 产品名称: | PD158780 |
| CAS No.: | 171179-06-9 |
| Chemical Name: | N4-(3-bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine |
| Synonyms: | PD 158780, PD-158780 |
| 分子量: | 330.18 |
| 分子式: | C₁₄H₁₂BrN₅ |
| SMILES: | CNC1=CC2=C(NC3=CC(Br)=CC=C3)N=CN=C2C=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD158780是有效地EGFR家族抑制剂；对EGFR，ErbB2，ErbB3和ErbB4的IC50值分别为8 μM，49，52，52 nM。 |
| IC50和靶点: | [{name:"EGFR:8 μM (IC50, Cell Assay)"},{name: "ErbB2:49 nM (IC50, Cell Assay)"},{name: "ErbB3:52 nM (IC50, Cell Assay)"},{name: "ErbB4:52 nM (IC50, Cell Assay)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Fry, D.W., Nelson, J.M., Slintak, V., et al.Biochemical and antiproliferative properties of 4-[Ar(alk)ylamino]pyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitorBiochem. Pharmacol.54,877-887(1997)
Gonzales, A.J., and Fry, D.W.G1 cell cycle arrest due to the inhibition of erbB family receptor tyrosine kinases does not require the retinoblastoma proteinExp. Cell Res.303,56-67(2005)
