Zorifertinib
Cat. No.：YN340212
CAS No. ：1626387-80-1
| 产品名称: | Zorifertinib |
| CAS No.: | 1626387-80-1 |
| Chemical Name: | (2R)-2,4-dimethyl-1-piperazinecarboxylic acid, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester |
| Synonyms: | AZD3759 |
| 分子量: | 459.90 |
| 分子式: | C₂₂H₂₃ClFN₅O₃ |
| SMILES: | ClC1=CC=CC(NC2=NC=NC3=CC(OC)=C(OC(N4[C@H](C)CN(C)CC4)=O)C=C23)=C1F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zorifertinib (AZD3759) 是一种有效的，具有口服活性的，可渗透中枢神经系统的EGFR抑制剂。作用于 EGFRwt，EGFRL858R和 EGFRexon 19Del，IC50分别为 0.3，0.2 和 0.2 nM。 |
| IC50和靶点: | [{name:"EGFR:0.3 nM (IC50)"},{name: "EGFRL858R:0.2 nM (IC50)"},{name: "EGFRExon 19 deletion:0.2 nM (IC50)"}] |
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Zeng, Q., Wang, J., Cheng, Z., et al.Discovery and evaluation of clinical candidate AZD3759, a potent, oral active, central nervous system-penetrant, epidermal growth factor receptor tyrosine kinase inhibitorJ. Med. Chem.58(20),8200-8215(2015)
