Lavendustin A
Cat. No.：YN340215
| 产品名称: | Lavendustin A |
| CAS No.: | 125697-92-9 |
| Chemical Name: | 5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-benzoic acid |
| Synonyms: | 薰草菌素; RG-14355 |
| 分子量: | 381.38 |
| 分子式: | C₂₁H₁₉NO₆ |
| SMILES: | O=C(O)C1=CC(N(CC2=CC(O)=CC=C2O)CC3=CC=CC=C3O)=CC=C1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lavendustin A (RG-14355), 可从Streptomyces Griseolavendus中分离得到，是一种有效的、特异性的、ATP竞争性的酪氨酸激酶抑制剂，对表皮生长因子受体 (EGFR) 相关酪氨酸激酶的IC50值为 11 ng/mL。 能抑制血管内皮生长因子诱导的血管生成，阻断LTPGABA-A的诱导。 |
| IC50和靶点: | |
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Hsu, C.-Y.J., Persons, P.E., Spada, A.P., et al.Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by lavendustin-A and its analogueJ. Biol. Chem.266(31),21105-21112(1991)
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