Olmutinib
Cat. No.：YN340223
CAS No. ：1353550-13-6
| 产品名称: | Olmutinib |
| CAS No.: | 1353550-13-6 |
| Chemical Name: | N-[3-[[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide |
| Synonyms: | HM61713, BI 1482694 |
| 分子量: | 486.59 |
| 分子式: | C₂₆H₂₆N₆O₂S |
| SMILES: | C=CC(NC1=CC=CC(OC2=C3C(C=CS3)=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Olmutinib (HM61713; BI-1482694) 是口服活性的，不可逆的第三代EGFR 酪氨酸激酶抑制剂，其与激酶结构域附近的半胱氨酸残基结合。Olmutinib 可用于非小细胞肺癌的研究。 |
| IC50和靶点: | [{name:"EGFRExon 19 deletion:9.2 nM (IC50, Cell Assay)"},{name: "EGFRL858R/T790M:10 nM (IC50, Cell Assay)"}] |
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Hu, X., Tang, S., Yang, F., et al.Design, synthesis, and antitumor activity of olmutinib derivatives containing acrylamide moietyMolecules26(10),3041(2021)
Zhong, J., Zhang, J., Yu, X., et al.Olmutinib reverses doxorubicin resistance in ETS1-overexpressing leukemia cellsMed. Sci. Monit.26,e924922(2020)
