Tyrphostin AG 879
Cat. No.：YN340229
CAS No. ：148741-30-4
| 产品名称: | Tyrphostin AG 879 |
| CAS No.: | 148741-30-4 |
| Chemical Name: | 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2E-propenethioamide |
| Synonyms: | AG 879 |
| 分子量: | 316.46 |
| 分子式: | C₁₈H₂₄N₂OS |
| SMILES: | S=C(N)/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tyrphostin AG 879 (AG 879) 是一种抑制TrKA磷酸化 (IC50为 10 μM) 但不抑制 TrKB 和_x000D_ TrKC 的酪氨酸激酶抑制剂。Tyrphostin AG 879 还是一种选择性的ErbB2酪氨酸激酶抑制剂，IC50为 1 μM，对ErbB2的选择性至少比 EGFR 高 500 倍。Tyrphostin AG 879 具有抗癌活性。 |
| IC50和靶点: | |
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He, H., Hiokawa, Y., Gazit, A., et al.The tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformationCancer Biol. Ther.3(1),96-101(2004)
Lee, H.K., Seo, I.A., Lee, S.H., et al.Tyrphostin ErbB2 inhibitors AG825 and AG879 have non-specific suppressive effects on gp130/ STAT3 signalingKorean J. Physiol. Pharmacol.12(5),281-286(2008)
