Neratinib
Cat. No.：YN340231
CAS No. ：698387-09-6
| 产品名称: | Neratinib |
| CAS No.: | 698387-09-6 |
| Chemical Name: | (2E)-N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide |
| Synonyms: | 来那替尼; HKI-272 |
| 分子量: | 557.04 |
| 分子式: | C₃₀H₂₉ClN₆O₃ |
| SMILES: | ClC1=C(OCC2=NC=CC=C2)C=CC(NC3=C(C#N)C=NC4=CC(OCC)=C(NC(/C=C/CN(C)C)=O)C=C43)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Neratinib 是一种具有口服活性的，不可逆的tyrosine kinase抑制剂，能够抑制 HER2 和 EGFR 的活性，IC50值分别为 59 nM 和 92 nM。 |
| IC50和靶点: | [{name:"HER2:59 nM (IC50)"},{name: "EGFR:92 nM (IC50)"}] |
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| Solvent & Solubility: |
Rabindran, S.K., Discafani, C.M., Rosfjord, E.C., et al.Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinaseCancer Res.64(11),3958-3965(2004)
Kavuri, S.M., Jain, N., Galimi, F., et al.HER2 activating mutations are targets for colorectal cancer treatmentCancer Discov.5(8),832-841(2015)
