Erlotinib
Cat. No.：YN340243
| 产品名称: | Erlotinib |
| CAS No.: | 183321-74-6 |
| Chemical Name: | N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine |
| Synonyms: | 埃罗替尼; CP-358774; NSC 718781; OSI-774 |
| 分子量: | 393.44 |
| 分子式: | C₂₂H₂₃N₃O₄ |
| SMILES: | C#CC1=CC=CC(NC2=NC=NC3=C2C=C(C(OCCOC)=C3)OCCOC)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Erlotinib (CP-358774) 是一种直接作用的EGFR酪氨酸激酶抑制剂，对人 EGFR 的IC50为 2 nM。Erlotinib 可降低完整肿瘤细胞的 EGFR 自磷酸化，IC50为 20 nM。Erlotinib 用于非小细胞肺癌的研究。 |
| IC50和靶点: | [{name:"EGFR:2 nM (IC50, Cell Free Assay)"}] |
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Herbst, R.S., and Bunn, P.A., Jr.Targeting the epidermal growth factor receptor in non-small cell lung cancerClin. Cancer Res.9(16),5813-5824(2003)
