Lapatinib
Cat. No.：YN340245
CAS No. ：231277-92-2
| 产品名称: | Lapatinib |
| CAS No.: | 231277-92-2 |
| Chemical Name: | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine |
| Synonyms: | 拉帕替尼; GW572016; GW2016 |
| 分子量: | 581.06 |
| 分子式: | C₂₉H₂₆ClFN₄O₄S |
| SMILES: | O=S(CCNCC1=CC=C(C2=CC=C3C(C(NC4=CC(Cl)=C(C=C4)OCC5=CC(F)=CC=C5)=NC=N3)=C2)O1)(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lapatinib (GW572016) 是一种ErbB-2和EGFR酪氨酸激酶结构域的有效抑制剂，对纯化的EGFR和ErbB-2的IC50值分别为 10.2 和 9.8 nM。 |
| IC50和靶点: | [{name:"EGFR:10.2 nM (IC50, Cell Free Assay)"},{name: "ErbB2:9.8 nM (IC50, Cell Free Assay)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Cho, T.P., Jun, F., Li, H., et al.Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitorsBioorg. Med. Chem. Lett.19(22),6437-6440(2009)
Wainberg, Z.A., Anghel, A., Desai, A.J., et al.Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivoClin. Cancer Res.16(5),1509-1519(2010)
Chefrour, M., Milano, G., Formento, P., et al.Positive interaction between lapatinib and capecitabine in human breast cancer models: Study of molecular determinantsFundam. Clin. Pharmacol.26(4),530-537(2012)
